In my opinion, the question is not truly coherent in that the maximisation of a likelihood and unbiasedness do not get along, if only because maximum likelihood estimators are equivariant, ie the transform of the estimator is the estimator of the transform of the parameter, while unbiasedness does not stand under non-linear transforms. Therefore, maximum likelihood estimators are almost never unbiased, if "almost" is considered over the range of all possible parametrisations.
However, there is an more direct answer to the question: when considering the estimation of the Normal variance, σ2, the UMVUE of σ2 is
σ^2n=1n−1∑i=1n{xi−x¯n}2
while the MLE of
σ2 is
σˇ2n=1n∑i=1n{xi−x¯n}2
Ergo, they differ. This implies that
if we have a best regular unbiased estimator, it must be the maximum
likelihood estimator (MLE).
does not hold in general.
Note further that, even when there exist unbiased estimators of a parameter θ, there is no necessarily a best unbiased minimum variance estimator (UNMVUE).